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Postmarketing surveillance voltaren pardozesanas has reported cases of severe hepatic reactions, including liver necrosis, jaundice, fulminant hepatitis with and without jaundice, and liver failure. Patients with Renal and or Hepatic Impairment To date, no differences in the pharmacokinetics of Diclofenac have been detected in studies of patients with renal 50 mg intravenously or hepatic impairment 100 mg oral solution. Urinary excretion of an additional metabolite half-life 80 hours accounts for only.